Schneider, Sabrina; Hartmann, Katrin; Dörfelt, René (2023): Influence of intravenous 10% amino acids infusion on serum albumin concentration in hypoalbuminemic dogs. Frontiers in Veterinary Science, 10: 1198534. ISSN 2297-1769
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Abstract
Objective: To evaluate the effect of parenteral amino acid application in hospitalized hypoalbuminemic dogs.
Materials and methods: Medical records of client-owned hypoalbuminemic dogs (albumin ≤ 25 g/L) were analyzed. Dogs receiving amino acids for only 1–2 days, receiving transfusions or surgery, or <6 months of age were excluded. Dogs were grouped as those receiving intravenous amino acids (AA, 80 dogs) over 3 days and longer, and those without additional amino acid treatment (CON, 78 dogs). Duration of hospitalization, albumin, and total protein concentrations were compared between groups by Mann–Whitney U test. Course of albumin and total protein concentration was evaluated by Friedman test and Dunn’s multiple comparison test. Significance was set to p ≤ 0.05.
Results: Dogs in group AA received 10% amino acid solution intravenously over median 4 days (3–11 days). No significant differences regarding survival and adverse effects were observed between groups. Dogs of group AA had significantly longer duration of hospitalization (median 8 days; 3–33 days) compared to group CON dogs (median 6 days, 3–24 days; p < 0.001). Initial albumin concentration was lower in group AA compared to CON ( p < 0.001). This difference was no longer present on day 2 ( p = 0.134).
Conclusions and clinical relevance: Intravenous application of 10% amino acid solution in hypoalbuminemic dogs can improve albumin concentration after 2 days, but does not influence outcome.
Doc-Type: | Article (LMU) |
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Organisational unit (Faculties): | 08 Veterinary Medicine > Centre for Clinical Veterinary Medicine > Medizinische Kleintierklinik |
DFG subject classification of scientific disciplines: | Life sciences |
Date Deposited: | 20. Jun 2023 07:15 |
Last Modified: | 07. Dec 2023 12:18 |
URI: | https://oa-fund.ub.uni-muenchen.de/id/eprint/794 |
DFG: | Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - 491502892 |