Influence of intravenous 10% amino acids infusion on serum albumin concentration in hypoalbuminemic dogs

Schneider, Sabrina; Hartmann, Katrin; Dörfelt, René (2023): Influence of intravenous 10% amino acids infusion on serum albumin concentration in hypoalbuminemic dogs. Frontiers in Veterinary Science, 10: 1198534. ISSN 2297-1769

Abstract

Objective: To evaluate the effect of parenteral amino acid application in hospitalized hypoalbuminemic dogs.

Materials and methods: Medical records of client-owned hypoalbuminemic dogs (albumin ≤ 25 g/L) were analyzed. Dogs receiving amino acids for only 1–2 days, receiving transfusions or surgery, or <6 months of age were excluded. Dogs were grouped as those receiving intravenous amino acids (AA, 80 dogs) over 3 days and longer, and those without additional amino acid treatment (CON, 78 dogs). Duration of hospitalization, albumin, and total protein concentrations were compared between groups by Mann–Whitney U test. Course of albumin and total protein concentration was evaluated by Friedman test and Dunn’s multiple comparison test. Significance was set to p ≤ 0.05.

Results: Dogs in group AA received 10% amino acid solution intravenously over median 4 days (3–11 days). No significant differences regarding survival and adverse effects were observed between groups. Dogs of group AA had significantly longer duration of hospitalization (median 8 days; 3–33 days) compared to group CON dogs (median 6 days, 3–24 days; p < 0.001). Initial albumin concentration was lower in group AA compared to CON ( p < 0.001). This difference was no longer present on day 2 ( p = 0.134).

Conclusions and clinical relevance: Intravenous application of 10% amino acid solution in hypoalbuminemic dogs can improve albumin concentration after 2 days, but does not influence outcome.

• Dokumententyp: Artikel (LMU)
• Organisationseinheit (Fakultäten): 08 Tiermedizin > Zentrum für Klinische Tiermedizin > Medizinische Kleintierklinik
• DFG-Fachsystematik der Wissenschaftsbereiche: Lebenswissenschaften
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 491502892