First Insights into the Occurrence of Circular Single-Stranded DNA Genomes in Asian and African Cattle

König, Marie-Thérèse; Frölich, Kai; Jandowsky, Anabell; Knauf-Witzens, Tobias; Langner, Christoph; Dietrich, Richard; Märtlbauer, Erwin; Didier, Andrea (2023): First Insights into the Occurrence of Circular Single-Stranded DNA Genomes in Asian and African Cattle. Animals, 13 (9). p. 1492. ISSN 2076-2615

Abstract

Circular replicase-encoding single-stranded (CRESS) DNA viruses and other circular DNA agents are increasingly found in various samples and animals. A specific class of these agents—termed bovine meat and milk factors (BMMF)—has been supposed to act as a factor in indirect carcino-genesis in humans. Initial observations attributed the BMMF to European cattle breeds and food-stuffs produced thereof. In the present study, blood and fecal samples from African and Asian cattle were examined. BMMF molecules and genomoviruses were detected in all bovids under study. The majority (79%) of the 29 circular elements could be assigned to BMMF groups 1 and 2, whereas CRESS viruses of the family Genomoviridae accounted for the smaller part (21%). Two genomoviruses belong to the genus Gemykibivirus and one to the genus Gemykrogvirus. The re-maining three might be considered as novel species within the genus Gemycircularvirus. The ma-jority of all isolated molecules originated from fecal samples, whereas only three derived from blood. The results from this study expand our knowledge on the diversity and presence of circular DNA in different ruminants that serve for food production in many countries over the world.

• Dokumententyp: Artikel (LMU)
• Organisationseinheit (Fakultäten): 08 Tiermedizin > Veterinärwissenschaftliches Department > Lehrstuhl für Hygiene und Technologie der Milch
• DFG-Fachsystematik der Wissenschaftsbereiche: Lebenswissenschaften
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 491502892