Brockmueller, Aranka; Mueller, Anna-Lena; Kunnumakkara, Ajaikumar B.; Aggarwal, Bharat B.; Shakibaei, Mehdi (2022): Multifunctionality of Calebin A in inflammation, chronic diseases and cancer. Frontiers in Oncology, 12. ISSN 2234-943X
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Veröffentlichte Publikation
fonc-12-962066.pdf

Abstract
Chronic diseases including cancer have high case numbers as well as mortality rates. The efficient treatment of chronic diseases is a major ongoing medical challenge worldwide, because of their complexity and many inflammatory pathways such as JNK, p38/MAPK, MEK/ERK, JAK/STAT3, PI3K and NF-κB among others being implicated in their pathogenesis. Together with the versatility of chronic disease classical mono-target therapies are often insufficient. Therefore, the anti-inflammatory as well as anti-cancer capacities of polyphenols are currently investigated to complement and improve the effect of classical anti-inflammatory drugs, chemotherapeutic agents or to overcome drug resistance of cancer cells. Currently, research on Calebin A, a polyphenolic component of turmeric (Curcuma longa), is becoming of growing interest with regard to novel treatment strategies and has already been shown health-promoting as well as anti-tumor properties, including anti-oxidative and anti-inflammatory effects, in diverse cancer cells. Within this review, we describe already known anti-inflammatory activities of Calebin A via modulation of NF-κB and its associated signaling pathways, linked with TNF-α, TNF-β and COX-2 and further summarize Calebin A’s tumor-inhibiting properties that are known up to date such as reduction of cancer cell viability, proliferation as well as metastasis. We also shed light on possible future prospects of Calebin A as an anti-cancer agent.
Dokumententyp: | Artikel (LMU) |
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Organisationseinheit (Fakultäten): | 07 Medizin > Anatomische Anstalt |
DFG-Fachsystematik der Wissenschaftsbereiche: | Lebenswissenschaften |
Veröffentlichungsdatum: | 13. Okt 2022 14:16 |
Letzte Änderung: | 07. Dez 2023 12:15 |
URI: | https://oa-fund.ub.uni-muenchen.de/id/eprint/258 |
DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 491502892 |