Keller, Patrick; Hu, Sheng; Nicola, Philip; Berger, Laurenz; Tamalunas, Alexander; Weinhold, Philipp; Stief, Christian G.; Hennenberg, Martin (2025): Voiding symptom severity varies independently from non-adrenergic prostate smooth muscle contractions in patients undergoing surgery for benign prostatic hyperplasia. Frontiers in Physiology, 16: 1612954. ISSN 1664-042X
![fphys-1-1612954.pdf [thumbnail of fphys-1-1612954.pdf]](https://oa-fund.ub.uni-muenchen.de/style/images/fileicons/text.png)
Veröffentlichte Publikation
fphys-1-1612954.pdf

Abstract
Background:
Resistance of voiding symptoms to α1-blockers in benign prostatic hyperplasia (BPH) has been provisionally explained by non-adrenergic prostate smooth muscle contraction. Here, we examined relationships between contractions and voiding symptoms in prostate tissues from laser-enucleation.
Methods:
Tissues were obtained from holmium and thulium laser enucleation. Contractions were induced by endothelin-1, U46619, noradrenaline and electric field stimulation (EFS). Emax values were analyzed for correlation with international prostate symptom score (IPSS), and compared to tissues from patients without surgery for BPH.
Results:
Noradrenaline- and EFS-induced contractions were higher with severe (IPSS 20–35) than moderate symptoms (IPSS 8–19) (Emax noradrenaline 66% vs 113% of KCl-induced contractions; EFS 33% vs 66%). Endothelin-1- and U46619-induced contractions were already maximum with moderate symptoms (endothelin-1 117% moderate, 135% severe; U46619 23%, 27%). Within 8–21 points, IPSS increased with Emax values for noradrenaline and EFS (r = 0.545, r = 0.448), but not with endothelin-1- or U46619-induced contractions. Endothelin-1-induced contractions were similar to noradrenaline-induced contractions (Emax endothelin-1 126% of KCl, noradrenaline 96%), and exceeded EFS- (52%) and U46619-induced contractions (25%). Emax values for endothelin-1 were similar between laser-enucleated patients and patients without surgery for BPH (127%), while Emax values for U46619 were higher in tissues from patients without surgery for BPH (59%) compared to laser-enucleated tissues.
Conclusion:
Symptom severity increases with α1-adrenergic, but not with non-adrenergic contractions in patients undergoing surgery for BPH. Endothelin-1-induced contractions are similar to noradrenaline-induced contractions. Conditions necessitating BPH surgery may not necessarily depend on α1-adrenergic tone, but may involve non-adrenergic contractions or factors beyond contraction.
Dokumententyp: | Artikel (Klinikum der LMU) |
---|---|
Organisationseinheit (Fakultäten): | 07 Medizin > Klinikum der LMU München > Urologische Klinik und Poliklinik |
DFG-Fachsystematik der Wissenschaftsbereiche: | Lebenswissenschaften |
Veröffentlichungsdatum: | 08. Sep 2025 06:19 |
Letzte Änderung: | 08. Sep 2025 06:19 |
URI: | https://oa-fund.ub.uni-muenchen.de/id/eprint/1886 |
DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 491502892 |