Logo Logo

Fang, Rong; Duering, Marco; Bode, Felix J.; Stösser, Sebastian; Meißner, Julius N.; Hermann, Peter; Liman, Thomas G.; Nolte, Christian H.; Kerti, Lucia; Ikenberg, Benno; Bernkopf, Kathleen; Glanz, Wenzel; Janowitz, Daniel; Wagner, Michael; Neumann, Katja; Speck, Oliver; Düzel, Emrah; Gesierich, Benno; Dewenter, Anna; Spottke, Annika; Waegemann, Karin; Görtler, Michael; Wunderlich, Silke; Zerr, Inga; Petzold, Gabor C.; Endres, Matthias; Georgakis, Marios K.; Dichgans, Martin ORCID: 0000-0002-0654-387X (2024): Risk factors and clinical significance of post‐stroke incident ischemic lesions. Alzheimer's & Dementia, 20 (12). pp. 8412-8428. ISSN 1552-5260

[thumbnail of Alzheimer_s___Dementia_-_2024_-_Fang_-_Risk_factors_and_clinical_significance_of_post‐stroke_incident_ischemic_lesions.pdf] Veröffentlichte Publikation
Alzheimer_s___Dementia_-_2024_-_Fang_-_Risk_factors_and_clinical_significance_of_post‐stroke_incident_ischemic_lesions.pdf

Die Publikation ist unter der Lizenz Creative Commons Namensnennung - Nicht-Kommerziell (CC BY-NC) verfügbar.

Herunterladen (1MB)

Abstract

INTRODUCTION
While incident ischemic lesions (IILs) are not unusual on follow-up magnetic resonance imaging (MRI) following stroke, their risk factors and prognostic significance remain unknown.

METHODS
In a prospective multicenter study of 503 acute stroke patients, we assessed IILs on registered MRI images at baseline and 6 months, analyzing risk factors and clinical outcomes across 36 months.

RESULTS
At 6 months, 78 patients (15.5%) had IILs, mostly diffusion-weighted imaging-positive (72%) and clinically covert (91%). Older age and small vessel disease (SVD) lesions were baseline risk factors for IILs. IILs were associated with worse cognitive (beta for global cognition: −0.31, 95% confidence interval [CI]: −0.48 to −0.14) and functional outcomes (beta for modified Rankin scale [mRS]: 0.36, 95% CI: 0.14 to 0.58), and higher recurrent stroke risk (hazard ratio: 3.81, 95% CI: 1.35 to 10.69). IILs partially explained the relationship between SVD and poor cognition.

DISCUSSION
IILs are common and are associated with worse cognitive and functional outcomes and stroke recurrence risk. Assessing IILs following stroke might aid prognostication.

Publikation bearbeiten
Publikation bearbeiten