Diagnosis and treatment of Parkinson´s disease (guideline of the German Society for Neurology)

Höglinger, Günter; Bähr, Mathias; Becktepe, Jos; Berg, Daniela; Brockmann, Kathrin; Buhmann, Carsten; Ceballos-Baumann, Andrés; Claßen, Joseph; Deuschl, Cornelius; Deuschl, Günther; Dodel, Richard; Ebersbach, Georg; Eggers, Carsten; van Eimeren, Thilo; Fanciulli, Alessandra; Fimm, Bruno; Folkerts, Ann-Kristin; Gausepohl, Madeleine; Hasan, Alkomiet; Hermann, Wiebke; Hilker-Roggendorf, Rüdiger; Höglinger, Günter; Höllerhage, Matthias; Hopfner, Franziska; Jost, Wolfgang; Kalbe, Elke; Kassubek, Jan; Klebe, Stephan; Klein, Christine; Klietz, Martin; Koeglsperger, Thomas; Kühn, Andrea; Krack, Paul; Krismer, Florian; Kuhlenbäumer, Gregor; Levin, Johannes; Liepelt-Scarfone, Inga; Lingor, Paul; Loewenbrück, Kai; Löhle, Matthias; Lorenzl, Stefan; Maaß, Sylvia; Maetzler, Walter; Menzel, Regina; Meyer, Philipp T; Mollenhauer, Brit; Neumann, Manuela; Odin, Per; Outeiro, Tiago; Pötter-Nerger, Monika; Reese, René; Reetz, Kathrin; Rieß, Olaf; Ruf, Viktoria; Schneider, Anja; Schrader, Christoph; Schnitzler, Alfons; Seppi, Klaus; Sixel-Döring, Friederike; Storch, Alexander; Tönges, Lars; Trenkwalder, Claudia; Walter, Uwe; Wächter, Tobias; Warnecke, Tobias; Wegner, Florian; Winkler, Christian; Witt, Karsten; Woitalla, Dirk; Zeuner, Kirsten; Trenkwalder, Claudia (2024): Diagnosis and treatment of Parkinson´s disease (guideline of the German Society for Neurology). Neurological Research and Practice, 6 (1). ISSN 2524-3489

Abstract

Introduction
The aim of this German national guideline is to optimize the clinical care of patients with Parkinson's disease (PD) in terms of diagnostics, drug and surgical treatment and care.

Summary or definition of the topic
This guidance was prepared for the German Society of Neurology (DGN) in collaboration with the Austrian Society of Neurology (ÖGN) and the Swiss Neurological Society (SNG) for German-speaking countries. The guidelines for the diagnosis and treatment of PD have been revised by a national expert group and the guideline commission of the DGN at S2k level. The main objective of these guidelines is to optimize the clinical care of PD patients regarding diagnosis, including early detection, technical diagnostic examinations, and pharmacological as well as invasive treatment options.

Recommendations
The updated PD diagnosis and treatment guidelines are emphasizing optimized clinical care. Key revisions include preferring the name "Parkinson's disease" over previous terms and adopting International Parkinson and Movement Disorder Society (MDS) diagnostic criteria. Recommendations cover genetic and imaging diagnostics, initial pharmacotherapy considering efficacy and patient factors, and tailored pharmacological combinations for complications. Guidelines extend to managing cognitive, affective, psychotic, and autonomic symptoms, along with non-oral therapies like pump therapy and deep brain stimulation. Special situations like akinetic crisis, driving ability, and care concepts are addressed, ensuring comprehensive management for PD patients at various stages and conditions.

Conclusions
This guidance reflects the state of the art at the beginning of 2024.

• Dokumententyp: Artikel (Klinikum der LMU)
• Organisationseinheit (Fakultäten): 07 Medizin > Klinikum der LMU München > Neurologische Klinik und Poliklinik mit Friedrich-Baur-Institut
• DFG-Fachsystematik der Wissenschaftsbereiche: Lebenswissenschaften
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 491502892