Harrer, Julia; Fejös, Csilla; Zablotski, Yury; Hirschberger, Johannes; Wolf, Georg; Rieger, Alexandra; Mayer, Christian; Dorsch, Roswitha (2022): Bacterial urinary tract infection and subclinical bacteriuria in dogs receiving antineoplastic chemotherapy. Journal of Veterinary Internal Medicine. pp. 1-11. ISSN 0891-6640
Veterinary Internal Medicne - 2022 - Harrer - Bacterial urinary tract infection and subclinical bacteriuria in dogs.pdf
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Abstract
Background: Immunosuppressive treatment with glucocorticoids and cyclosporine increases the risk for positive urine cultures (PUCs) in dogs.
Objective: To investigate the prevalence and incidence of PUC in dogs diagnosed with cancer and treated with antineoplastic chemotherapy while distinguishing between subclinical bacteriuria (SB) and urinary tract infection (UTI).
Animals: Forty-six client-owned dogs with nonurogenital cancer treated with anti- neoplastic chemotherapy.
Methods: Prospective observational longitudinal clinical study. Dogs in which a urine culture was performed before the start of and at least once during antineoplastic chemotherapy were included. A McNemar's test was used to investigate if the preva- lence of PUC increased during antineoplastic chemotherapy. Positive urine cultures were categorized into SB and UTI and multiple PUCs from the same dog and cate- gory were grouped together as 1 episode of PUC.
Results: Urine culture was positive in 21/185 urine samples in 8/46 dogs. Antineo- plastic chemotherapy did not influence the prevalence of PUC (P = 1.00), which was 11% (5/46 dogs; 95% confidence interval: 5-23%) before the start of and 13% (6/46 dogs; 95% confidence interval: 6-26%) during antineoplastic chemotherapy. Eight dogs had 10 episodes of PUC; 7/10 episodes were classified as SB, and in 3/10 epi- sodes UTI (chronic prostatitis, prostatic abscess, and emphysematous cystitis) was diagnosed. Escherichia coli was the most common pathogen, isolated in 9/10 episodes.
Conclusions and Clinical Importance: We did not find evidence that antineoplastic chemotherapy is a major predisposing factor for the development of PUC. Most dogs with PUC had SB.
Doc-Type: | Article (LMU) |
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Organisational unit (Faculties): | 08 Veterinary Medicine > Department of Veterinary Medicine > Lehrstuhl für Bakteriologie und Mykologie 08 Veterinary Medicine > Centre for Clinical Veterinary Medicine > Institut für Tierpathologie |
DFG subject classification of scientific disciplines: | Life sciences |
Date Deposited: | 03. Jun 2022 09:30 |
Last Modified: | 07. Dec 2023 12:15 |
URI: | https://oa-fund.ub.uni-muenchen.de/id/eprint/110 |
DFG: | Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - 491502892 |