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Storr, Martin; Andresen, V.; Frieling, T.; Gschossmann, J. M.; Keller, J.; Langhorst, J.; Pehl, C.; Stengel, A.; Tebbe, J.; Wiemer, K.; Madisch, A.; Stengel, M.; Negi, Shweta (2026): S1 Guideline of the German Society for Neurogastroenterology and Motility (DGNM) on Functional Dyspepsia (FD), a Disorder of Gut–Brain Interaction (DGBI). Gastroenterology Research and Practice, 2026: 2610765. ISSN 1687-6121

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Gastroenterology_Research_and_Practice_-_2026_-_Storr_-_S1_Guideline_of_the_German_Society_for_Neurogastroenterology_and.pdf

Abstract

Functional dyspepsia (FD) is common and classified as a disorder of gut–brain interaction (DGBI). The prevalence is estimated around 10% of the population. Diagnosis is based on symptoms, which are classified according to the Rome IV criteria, in combination with diagnostic procedures that may include laboratory testing, Helicobacter pylori testing, upper gastrointestinal endoscopy, abdominal ultrasound, and other examinations, depending on the severity, duration, and presence of alarm symptoms. Therapeutic procedures include psychoeducation, dietary counseling, mind–body procedures, psychotherapy, and medication. The S1 guideline summarizes the current state of knowledge and allows a targeted approach based on the currently available medical evidence.

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