When mitochondria lose their fold: matrix proteostasis and stress signaling

Bertram, Nils; Mokranjac, Dejana (2026): When mitochondria lose their fold: matrix proteostasis and stress signaling. Frontiers in Physiology, 17: 1873221. ISSN 1664-042X

Abstract

A dedicated network of chaperones and proteases is present in the mitochondrial matrix that orchestrates import, folding, disaggregation and eventually degradation of proteins. When this network is overwhelmed, unfolded or misfolded proteins accumulate in different types of aggregates which may either support recovery of functional proteins, initiate spatial sequestration or drive toxic aggregation. Here, we discuss mitochondrial protein aggregation and how mitochondrial proteostasis stress is communicated to the rest of the cell.

• Doc-Type: Article (LMU)
• Organisational unit (Faculties): 19 Biology
• DFG subject classification of scientific disciplines: Natural sciences
• DFG: Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - 491502892
• DFG: Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - 406246262
• DFG: Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - 450889947