Associations between COVID-19 severity, cognitive impairment, and quality of life in individuals in need of care: Results from the multicenter registry study BaCoM

Lukaschek, Karoline ; Hofbauer, Sophia; Dreischulte, Tobias; Drey, Michael; Rottenkolber, Marietta; Winter, Susanne; Sebastião, Maria; Teupser, Daniel; Gágyor, Ildikó; Hausen, Anita; Hoelscher, Michael; Janke, Christian; Kühlein, Thomas; Gensichen, Jochen (2026): Associations between COVID-19 severity, cognitive impairment, and quality of life in individuals in need of care: Results from the multicenter registry study BaCoM. Dementia and Geriatric Cognitive Disorders Extra, 16 (1). pp. 71-84. ISSN 1664-5464

Abstract

Introduction: Older adults in need of care are at high risk for severe COVID-19 and cognitive impairment. This study investigates the association between COVID-19 severity, quality of life, and cognitive impairment in individuals requiring care.

Methods: Data from 531 participants (68.4% female; n = 363; median age = 82.0 years, interquartile range = 13.0) of the Bavarian ambulatory COVID-19 Monitor (BaCoM) – all of whom were in need of care and had a prior SARS-CoV-2 infection – were analysed. We compared sociodemographic and health-related characteristics, cognitive performance, COVID-19 disease features, and quality of life between 80 individuals hospitalized for COVID-19 and 451 individuals who were infected but not hospitalized. Associations between cognitive impairment and COVID-19 severity were examined using binary logistic regressions with the MoCA Blind and Six-Item Screener as dependent variables. The association between quality of life and COVID-19 severity was analysed using multiple linear regression with the EQ VAS as the dependent variable.

Results: Hospitalized individuals had significantly lower MoCA Blind scores than non-hospitalized peers (17.0 vs. 19.0, p = 0.039), while SIS scores showed no difference. EQ VAS scores were similar between the groups, but hospitalized individuals had lower EQ-5D-5L Index scores (0.57 vs. 0.75, p = 0.004). COVID-19 severity (hospitalization, symptom duration) was not associated with MoCA Blind <18 or with the EQ VAS.

Conclusion: The study found lower MoCA-Blind scores and reduced quality of life in hospitalized individuals, but adjusted analyses showed no significant link between COVID-19 severity and cognition or quality of life.

• Dokumententyp: Artikel (Klinikum der LMU)
• Organisationseinheit (Fakultäten): 07 Medizin > Institut für Allgemeinmedizin