Is surgery with curative intent feasible in old and very old patients with non-small cell lung cancer? – Experience of a certified lung cancer center over one decade

Zimmermann, Julia; Walter, Julia; Samm, Nicole; Damirov, Fuad; Reinmuth, Niels; Kauffmann-Gerrero, Diego; Hatz, Rudolf A.; Tufman, Amanda; Schneider, Christian P. (2026): Is surgery with curative intent feasible in old and very old patients with non-small cell lung cancer? – Experience of a certified lung cancer center over one decade. Langenbeck's Archives of Surgery, 411: 92. ISSN 1435-2451

Abstract

Purpose

Non-small cell lung cancer (NSCLC) accounts for 80% of all lung cancers and, like most other cancers, is a disease of advanced age. This study analyzed the question of whether surgical treatment for non-small cell lung cancer (NSCLC) in elderly patients is acceptable in all operable stages with curative intent.

Methods

In this retrospective analysis, we used data of all NSCLC patients aged over 60 who underwent lobectomy at the Lung Cancer Centre Munich between 2011–2020 and divided them into four groups in ascending order of age. We performed Kaplan–Meier survival analysis and multivariate Cox regression to compare progression-free survival (PFS) and overall survival (OS) between the age groups. To compare numerical outcomes between the age groups we used analysis of variance (ANOVA), and Chi2-test for categorical outcomes.

Results

Of 1680 patients undergoing lobectomy, 1221 met our inclusion criteria. It was found that the length of hospital stay increased with advanced age and was significantly longer in older patients (p < 0.001). Although the older patients had more comorbidities, only cardiac arrhythmias occurred significantly more often in the postoperative phase (p = 0.02). Kaplan–Meier survival analysis and multivariate Cox regression analysis showed significantly poorer OS for patients aged over 80 compared to patients aged between 60 to 69. PFS was not significantly associated with age.

Conclusion

Surgery with curative intent is feasible in old and very old patients with NSCLC and the oncological outcome is comparable. However, we recommend individual selection in view of patient age.

• Dokumententyp: Artikel (Klinikum der LMU)
• Organisationseinheit (Fakultäten): 07 Medizin > Klinikum der LMU München > Medizinische Klinik und Poliklinik V (Pneumologie)
• DFG-Fachsystematik der Wissenschaftsbereiche: Lebenswissenschaften
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 491502892