Resection of a singular metachronous testicular metastasis of prostate cancer: A case report

Semmler, Marie; Brinkmann, Isabel; Aydogdu, Can; Pyrgidis, Nikolaos; Kidess, Marc; Ebner, Benedikt; Ledderose, Stephan; Stief, Christian G.; Marcon, Julian; Apfelbeck, Maria; Chaloupka, Michael (2025): Resection of a singular metachronous testicular metastasis of prostate cancer: A case report. Current Problems in Cancer: Case Reports, 18: 100370. ISSN 26666219

Abstract

We present the case of a 66-year-old patient with a biochemical recurrence of prostate cancer manifesting as an asymptomatic testicular metastasis. Two years after radical prostatectomy and salvage radiation, the prostate-specific antigen (PSA) level rose to 1.07ng/ml. PSMA PET/CT scan showed tracer accumulation in the left testicle. Inguinal orchiectomy confirmed the metastasis. After being non-detectable, the PSA level increased five months after orchiectomy, with PSMA PET/CT revealing positive iliac lymph nodes. In summary, the presented case illustrates orchiectomy as a metastasectomy. However, apart from a transient decrease in PSA, no medium-term oncological advantage could be seen.

• Doc-Type: Article (LMU Hospital)
• Organisational unit (Faculties): 07 Medicine > Medical Center of the University of Munich > Urology Clinic and Polyclinic
• DFG subject classification of scientific disciplines: Life sciences
• DFG: Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - 494502892