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Rauchmann, Boris-Stephan; Gross, Patrizia; Ersoezlue, Ersin; Wagner, Michael; Ballarini, Tommaso; Kurz, Carolin; Tatò, Maia; Utecht, Julia; Papazov, Boris; Guersel, Selim; Totzke, Marie; Trappmann, Lena; Burow, Lena; Koller, Gabriele; Stöcklein, Sophia; Keeser, Daniel; Altenstein, Slawek; Bartels, Claudia; Buerger, Katharina; Dechent, Peter; Dobisch, Laura; Ewers, Michael; Fliessbach, Klaus; Freiesleben, Silka Dawn; Glanz, Wenzel; Goeerss, Doreen; Gref, Daria; Haynes, John Dylan; Janowitz, Daniel; Kilimann, Ingo; Kimmich, Okka; Kleineidam, Luca; Laske, Christoph; Lohse, Andrea; Maier, Franziska; Metzger, Coraline D.; Munk, Matthias H.; Peters, Oliver; Preis, Lukas; Priller, Josef; Roeske, Sandra; Roy, Nina; Sanzenbacher, Carolin; Scheffler, Klaus; Schneider, Anja; Schott, Björn Hendrik; Spottke, Annika; Spruth, Eike Jakob; Teipel, Stefan; van Lent, Debora Melo; Wiltfang, Jens; Wolfsgruber, Steffen; Yakupov, Renat; Düzel, Emrah; Jessen, Frank; Perneczky, Robert (2023): A 6-items Questionnaire (6-QMD) captures a Mediterranean like dietary pattern and is associated with memory performance and hippocampal volume in elderly and persons at risk for Alzheimer’s disease. Nutrition and Healthy Aging, 8 (1). pp. 143-156. ISSN 24519480

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Abstract

A 6-items Questionnaire (6-QMD) captures a Mediterranean like dietary pattern and is associated with memory performance and hippocampal volume in elderly and persons at risk for Alzheimer’s disease Boris-Stephan Rauchmann Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany Institute of Neuroradiology, University Hospital, LMU Munich, Munich, Germany German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK Patrizia Gross Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany Ersin Ersoezlue Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany Michael Wagner German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany Tommaso Ballarini German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany Carolin Kurz Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany Maia Tatò Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany Julia Utecht Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany Boris Papazov Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany Selim Guersel Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany Marie Totzke Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany Lena Trappmann Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany Lena Burow Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany Gabriele Koller Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany Sophia Stöcklein Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany Daniel Keeser Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany Slawek Altenstein German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany Claudia Bartels Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen, Germany Katharina Buerger German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany Peter Dechent Department of Cognitive Neurology, MR-Research in Neuroscience, Georg-August-University Göttingen, Germany Laura Dobisch German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany Michael Ewers German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany Klaus Fliessbach German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany Silka Dawn Freiesleben German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany Department of Psychiatry, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany Wenzel Glanz German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany Doreen Goeerss Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany Daria Gref German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany Department of Psychiatry, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany John Dylan Haynes Bernstein Center for Computational Neuroscience, Charité – Universitätsmedizin, Berlin, Germany Daniel Janowitz Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany Ingo Kilimann German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany Okka Kimmich German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany Luca Kleineidam German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany Christoph Laske German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany Andrea Lohse Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany Franziska Maier Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany Coraline D. Metzger German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany Matthias H. Munk German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany Oliver Peters German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany Lukas Preis Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany Josef Priller German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University Munich, Munich, Germany Sandra Roeske German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany Nina Roy German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany Carolin Sanzenbacher German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany Klaus Scheffler Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany Anja Schneider German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany Björn Hendrik Schott German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen, Germany Leibniz Institute for Neurobiology, Magdeburg, Germany Annika Spottke German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany Department of Neurology, University of Bonn, Bonn, Germany Eike Jakob Spruth German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany Stefan Teipel Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany Debora Melo van Lent Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, UT Health San Antonio, Texas, USA Jens Wiltfang German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen, Germany Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal Steffen Wolfsgruber Department of Psychiatry, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany Renat Yakupov German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany Emrah Düzel German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany Frank Jessen German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Köln, Germany Robert Perneczky Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK

BACKGROUND: There is evidence that adherence to Mediterranean-like diet reduces cognitive decline and brain atrophy in Alzheimer's disease (AD). However, lengthy dietary assessments, such as food frequency questionnaires (FFQs), discourage more frequent use. OBJECTIVE: Here we aimed to validate a 6-items short questionnaire for a Mediterranean-like diet (6-QMD) and explore its associations with memory performance and hippocampal atrophy in healthy elders and individuals at risk for AD. METHODS: We analyzed 938 participants (N = 234 healthy controls and N = 704 participants with an increased AD risk) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE). The 6-QMD was validated against the Mediterranean Diet (MeDi) score and the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) score, both derived from a detailed FFQ. Furthermore, associations between the 6-QMD and memory function as well as hippocampal atrophy were evaluated using linear regressions. RESULTS: The 6-QMD was moderately associated with the FFQ-derived MeDi adherence score (ρ = 0.25, p < 0.001) and the MIND score (ρ = 0.37, p= < 0.001). Higher fish and olive oil consumption and lower meat and sausage consumption showed significant associations in a linear regression, adjusted for diagnosis, age, sex and education, with memory function (β = 0.1, p = 0.008) and bilateral hippocampal volumes (left: β = 0.15, p < 0.001); (right: β = 0.18, p < 0.001)). CONCLUSIONS: The 6-QMD is a useful and valid brief tool to assess the adherence to MeDi and MIND diets, capturing associations with memory function and brain atrophy in healthy elders and individuals at increased AD dementia risk, making it a valid alternative in settings with time constraints.
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