Logo Logo

Börner-Schröder, Corinna; Lang, Magdalena; Urban, Giada; Zaidenstadt, Erik; Staisch, Jacob; Hauser, Ari; Hannibal, Iris; Huß, Kristina; Klose, Birgit; Lechner, Matthias F.; Sollmann, Nico; Landgraf, Mirjam N.; Heinen, Florian; Bonfert, Michaela V. (2023): Neuromodulation in Pediatric Migraine using Repetitive Neuromuscular Magnetic Stimulation: A Feasibility Study. Children, 10 (11): 1764. ISSN 2227-9067

[thumbnail of 2023 Börner-Schröder rNMS Kids&Teens Studie.pdf] Published Article
2023 Börner-Schröder rNMS Kids&Teens Studie.pdf

The publication is available under the license Creative Commons Attribution.

Download (1MB)


Migraine has a relevant impact on pediatric health. Non-pharmacological modalities for its management are urgently needed. This study assessed the safety, feasibility, acceptance, and efficacy of repetitive neuromuscular magnetic stimulation (rNMS) in pediatric migraine. A total of 13 patients with migraine, ≥6 headache days during baseline, and ≥1 myofascial trigger point in the upper trapezius muscles (UTM) received six rNMS sessions within 3 weeks. Headache frequency, intensity, and medication intake were monitored using headache calendars; headache-related impairment and quality of life were measured using PedMIDAS and KINDL questionnaires. Muscular involvement was assessed using pressure pain thresholds (PPT). Adherence yielded 100%. In 82% of all rNMS sessions, no side effects occurred. All participants would recommend rNMS and would repeat it. Headache frequency, medication intake, and PedMIDAS scores decreased from baseline to follow-up (FU), trending towards statistical significance (p = 0.089; p = 0.081, p = 0.055). A total of 7 patients were classified as responders, with a ≥25% relative reduction in headache frequency. PPT above the UTM significantly increased from pre- to post-assessment, which sustained until FU (p = 0.015 and 0.026, respectively). rNMS was safe, feasible, well-accepted, and beneficial on the muscular level. The potential to reduce headache-related symptoms together with PPT changes of the targeted UTM may underscore the interplay of peripheral and central mechanisms conceptualized within the trigemino-cervical complex.

View Item
View Item